反应详情

温度

90 °C

A mixture of 5-chloro-3-cyclohexyl-1,2,4-thiadiazole (32.0 mg, 158 μmol), 1-(4-methoxyphenethyl)piperazine dihydrochloride (51.0 mg, 174 μmol) and DIPEA in EtOH was heated for 30 min at an oil bath temperature of 90° C. The mixture was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3 to yield after evaporation of the product containing fractions 13.7 mg (22%) of the title compound as light brown solid. MS (m/e): 387.3 (MH+).

1. customThe mixture was subjected to purification by preparative HPLC on reversed phase
2. washeluting with a gradient
3. customformed from acetonitrile, water and NEt3
4. customto yield
5. customafter evaporation of the product
6. additioncontaining fractions 13.7 mg (22%) of the title compound as light brown solid