反应详情

温度

0 °C

10 g (45.32 mmol) of 4-(hydroxymethyl)-N-methylpyridine-2-carboxamide (Example 40A) were suspended in 160 ml of dichloromethane and cooled to 0° C. 16.18 g (135.96 mmol) of thionyl chloride were added, and the reaction mixture was then warmed to RT and stirred at RT overnight. The reaction mixture was evaporated and dried under high vacuum.

1. temperaturethe reaction mixture was then warmed to RT
2. customThe reaction mixture was evaporated
3. customdried under high vacuum