HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714447Generated: October 29, 2026
Thionyl Chloride → 4-(chloromethyl)-N-methylpyridine-2-carboxamide hydrochloride
https://huagongshe.com/reaction/714447
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Hydroxymethyl)-N-methylpyridine-2-carboxamide | HCID 23439277 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(chloromethyl)-N-methylpyridine-2-carboxamide hydrochloride | HCID 66631580 | — |
Reaction Steps
10 g (45.32 mmol) of 4-(hydroxymethyl)-N-methylpyridine-2-carboxamide (Example 40A) were suspended in 160 ml of dichloromethane and cooled to 0° C. 16.18 g (135.96 mmol) of thionyl chloride were added, and the reaction mixture was then warmed to RT and stirred at RT overnight. The reaction mixture was evaporated and dried under high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187428B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-9ea5636fb553480990f9c5f041430c7e |
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| Source note | uspto-grants-2015_11 |
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