Trifluoroacetic acid → HCID 17925871, compound

HRID 714512Notes

Reaction equation

HRID 714512 reaction equation
C([O:5][C:6](=[O:19])[CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:17]([O:16][C:14]([CH:11]1[CH2:12][CH2:13][C:8](=[CH:7][C:6]([OH:19])=[O:5])[CH2:9][CH2:10]1)=[O:15])[CH3:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18340695HCID 18340695, compound

Product 1

HCID 17925871HCID 17925871, compoundYield 134.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of ethyl 4-(2-tert-butoxy-2-oxoethylidene)cyclohexanecarboxylate (5.3 g, 21 mmol) in CH2Cl2 (30 ml) was added TFA (30 ml). The solution was stirred at room temperature overnight. The solution was concentrated in vacuo to afford 6 g of product as colorless oil, which was used directly for next step without further purification.

Workup

  1. concentrationThe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-bea00d74b052408f9587690813472c8b
Source dataset
uspto-grants-2015_11
Patent number
US09187447B2

Reaction notes

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