Trifluoroacetic acid → HCID 131734059, compound

HRID 714533Notes

Reaction equation

HRID 714533 reaction equation
[CH3:1][CH:2]([CH3:27])[CH2:3][NH:4][C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:19][CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH2:9][CH2:8]1)=[O:6].[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[OH:34][C:28]([C:30]([F:33])([F:32])[F:31])=[O:29].[NH:16]1[CH2:17][CH2:18][CH2:19][CH:13]([N:10]2[CH2:11][CH2:12][CH:7]([C:5]([NH:4][CH2:3][CH:2]([CH3:27])[CH3:1])=[O:6])[CH2:8][CH2:9]2)[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117678217HCID 117678217, compound

Product 1

HCID 131734059HCID 131734059, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(4-((2-methylpropyl)carbamoyl)piperidin-1-yl)azepane-1-carboxylate (1.95 g, 5.1 mmol) was dissolved in DCM (16 mL) and TFA (4 mL) was added. The reaction mixture was stirred at rt for 2 h under nitrogen, then the solvents were removed in vacuo, to give 1-(azepan-4-yl)-N-(2-methylpropyl)piperidine-4-carboxamide TFA salt (2.02 g), Intermediate 5, as a dark yellow oil which was used directly without further purification.

Workup

  1. customthe solvents were removed in vacuo

Sources & evidence

ORD record
ord-da4ea07e9c364ae79acab982afde7947
Source dataset
uspto-grants-2015_11
Patent number
US09187451B2

Reaction notes

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