Hydrochloric Acid → HCID 71536482, compound

HRID 714562Notes

Reaction equation

HRID 714562 reaction equation
[OH:1][CH:2]([CH2:18][N:19]1[C:32]2[CH:31]=[C:30]([C:33]([F:36])([F:35])[F:34])[CH:29]=[CH:28][C:27]=2[S:26][C:25]2[C:20]1=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:3][N:4]1[CH2:17][C:6]2([CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[CH2:5]1.Cl>C(Cl)Cl>[CH2:5]1[C:6]2([CH2:7][NH:8][CH2:9]2)[CH2:17][N:4]1[CH2:3][CH:2]([OH:1])[CH2:18][N:19]1[C:32]2[CH:31]=[C:30]([C:33]([F:35])([F:34])[F:36])[CH:29]=[CH:28][C:27]=2[S:26][C:25]2[C:20]1=[CH:21][CH:22]=[CH:23][CH:24]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86731038HCID 86731038, compound

Product 1

HCID 71536482HCID 71536482, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (±)-tert-butyl 6-(2-hydroxy-3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-2,6-diazaspiro[3.3]heptane-2-carboxylate and CH2Cl2 was reacted with HCl (0.13 mL, 0.52 mmol, 4.0N solution in dioxane). The reaction mixture was stirred for 12 h. Once no starting material was observed by analytical LCMS, the reaction mixture was concentrated. The residue was purified by flash chromatography on silica gel (0-100% EtOAc in hexanes) to afford the title compound. LCMS m/z 422 (M+H)

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was purified by flash chromatography on silica gel (0-100% EtOAc in hexanes)

Sources & evidence

ORD record
ord-495213b2ec984980889b44109f74b8cd
Source dataset
uspto-grants-2015_11
Patent number
US09187439B2

Reaction notes

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