Sodium Iodide → HCID 86731039, compound

HRID 714564Notes

Reaction equation

HRID 714564 reaction equation
Cl[CH2:2][CH2:3][CH2:4][N:5]1[C:18]2[CH:17]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:15]=[CH:14][C:13]=2[S:12][C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2.[Na+].[I-:24]>CC(C)=O>[I:24][CH2:2][CH2:3][CH2:4][N:5]1[C:18]2[CH:17]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:15]=[CH:14][C:13]=2[S:12][C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 7429410-(3-Chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine

Product 1

HCID 86731039HCID 86731039, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
55 °C

Procedure

A solution of 10-(3-chloropropyl)-2-(trifluoromethyl)-10H-phenothiazine was mixed with acetone (50 mL) and NaI (4.0 g, 26 mmol) and heated at 55° C. for 48 h. Once no starting material was observed by analytical LCMS, the reaction mixture was partitioned between CH2Cl2 (100 mL) and an aqueous solution of Na2S2O3 (20 ml). The organic layer is dried with MgSO4 and concentrated to afford the title compound.

Workup

  1. customthe reaction mixture was partitioned between CH2Cl2 (100 mL)
  2. dry with materialThe organic layer is dried with MgSO4
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-00bf868a77864436b0b5d7d98a152e90
Source dataset
uspto-grants-2015_11
Patent number
US09187439B2

Reaction notes

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