Methyl iodide → HCID 56592474, compound

HRID 714586Notes

Reaction equation

HRID 714586 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:17]2[C:26]3[C:21](=[CH:22][C:23]([O:37][CH:38]4[CH2:42][CH2:41][O:40][CH2:39]4)=[C:24]([NH:27][C:28](=[O:36])[CH:29]=[C:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[CH:25]=3)[N:20]=[CH:19][C:18]=2[C:43]#[N:44])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.[C:45](=O)([O-])[O-].[K+].[K+].CI>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:17]2[C:26]3[C:21](=[CH:22][C:23]([O:37][CH:38]4[CH2:42][CH2:41][O:40][CH2:39]4)=[C:24]([NH:27][C:28](=[O:36])[CH:29]=[C:30]4[CH2:35][CH2:34][N:33]([CH3:45])[CH2:32][CH2:31]4)[CH:25]=3)[N:20]=[CH:19][C:18]=2[C:43]#[N:44])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 56591959HCID 56591959, compound

Product 1

HCID 56592474HCID 56592474, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a single-neck reaction flask (50 ml) was added the product of Example 30 (20 mg). The product was dissolved in acetonitrile (10 ml). To the resultant solution were added anhydrous potassium carbonate powders (20 mg) and methyl iodide (5 mg). The resulting mixture was stirred at the room temperature. After the reaction finished, the resultant substance was filtered. The filtrate was rotary-evaporated to dryness to give a crude product. The crude product was purified with thin layer chromatography (developing solvent: chloroform:methanol=92:8).

Workup

  1. filtrationthe resultant substance was filtered
  2. customThe filtrate was rotary-evaporated to dryness

Sources & evidence

ORD record
ord-7f2e554789634960903e819cfa26e6a9
Source dataset
uspto-grants-2015_11
Patent number
US09187458B2

Reaction notes

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