反应详情

温度

50 °C

At 50° C., 5.00 g (29.3 mmol) of 4-chlorobenzohydrazide were suspended in 150 ml of dry THF. 2.63 ml (29.9 mmol) of allyl isocyanate, dissolved in 110 ml of dry THF, were then added dropwise. Initially, all of the starting material dissolved, and then a fine precipitate formed. The mixture was stirred at 50° C. for 2 h. After cooling to room temperature, diethyl ether was added. The colorless solid was filtered off with suction, washed with diethyl ether and dried under high vacuum. This gave 7.42 g (100% of theory) of the target compound.

1. customAt 50° C.
2. additionwere then added dropwise
3. dissolutionInitially, all of the starting material dissolved
4. customa fine precipitate formed
5. temperatureAfter cooling to room temperature
6. filtrationThe colorless solid was filtered off with suction
7. washwashed with diethyl ether
8. customdried under high vacuum