5-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one → HCID 86690916, compound

HRID 714678Notes

Reaction equation

HRID 714678 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:19])([F:18])[F:17])[C:10](=[O:13])[NH:11][N:12]=2)=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[S:24][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:34]([F:37])([F:36])[F:35])=[N:26][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:14][C@H:15]([OH:20])[C:16]([F:18])([F:19])[F:17])[C:10](=[O:13])[N:11]([CH2:22][C:23]3[S:24][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[C:34]([F:37])([F:35])[F:36])=[N:26][N:27]=3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 595368365-(4-Chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-oneHCID 67412369HCID 67412369, compound

Product 1

HCID 86690916HCID 86690916, compound

Procedure

Analogously to the preparation of Example 18, 33 mg (0.11 mmol) of the compound from Example 5A were reacted with 35 mg (0.11 mmol) of the compound from Example 85A. This gave 16 mg (27% of theory) of the target compound.

Sources & evidence

ORD record
ord-f2461422d2ef4427810512284d124260
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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