HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714679Generated: October 29, 2026
3-(Trifluoromethyl)benzene-1-carboximidamide hydrochloride → HCID 178517577, compound
https://huagongshe.com/reaction/714679
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Trifluoromethyl)benzene-1-carboximidamide hydrochloride | HCID 2730243 | — |
| Reactant | 2-[3-(4-Chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetohydrazide | HCID 67406141 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178517577 | HCID 178517577 | — |
Reaction Steps
100 mg (0.33 mmol) of the compound from Example 21A were dissolved in 1.6 ml of DMF, 109 mg (0.49 mmol) of 3-trifluoromethylbenzamidine hydrochloride were added and the mixture was stirred in a microwave oven at 150° C. for 45 min. After cooling, the reaction was concentrated under reduced pressure on a rotary evaporator and the residue that remained was purified chromatographically [Method 19]. This gave 70 mg (47% of theory) of the target compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187466B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-7776442412b447298097e5c2edb199e7 |
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| Source note | uspto-grants-2015_11 |
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