反应详情

温度

150 °C

100 mg (0.33 mmol) of the compound from Example 21A were dissolved in 1.6 ml of DMF, 109 mg (0.49 mmol) of 3-trifluoromethylbenzamidine hydrochloride were added and the mixture was stirred in a microwave oven at 150° C. for 45 min. After cooling, the reaction was concentrated under reduced pressure on a rotary evaporator and the residue that remained was purified chromatographically [Method 19]. This gave 70 mg (47% of theory) of the target compound as a colorless solid.

1. temperatureAfter cooling
2. concentrationthe reaction was concentrated under reduced pressure on a rotary evaporator
3. customthe residue that remained was purified chromatographically [Method 19]