反应详情

温度

50 °C

62 mg (0.11 mmol) of the compound from Example 28 were suspended in 1 ml of ethanol, and 213 μl (0.21 mmol) of 1 M aqueous sodium hydroxide solution were added. The mixture was stirred at 50° C. for 4 h. After cooling to RT, the reaction was neutralized with 215 μl of 1 M hydrochloric acid and concentrated under reduced pressure, and the residue was purified by chromatography [Method 19]. This gave 37 mg (61% of theory) of the target compound as a colorless foam.

1. temperatureAfter cooling to RT
2. concentrationconcentrated under reduced pressure
3. customthe residue was purified by chromatography [Method 19]