反应详情

温度

50 °C

124 mg (0.36 mmol) of the compound from Example 14A were dissolved in 2 ml of acetonitrile, and 0.6 mg (0.003 mmol) of copper(II) acetate monohydrate and 56 mg (0.30 mmol) of 1-azido-2,3-dichlorobenzene were added. The mixture was stirred at 50° C. for 2 h. For work-up, the crude mixture was allowed to cool to RT and filtered through a little silica gel. The product was eluted with ethyl acetate and the solution obtained was concentrated under reduced pressure. The crude product was then purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 1:1). This gave 61 mg (31% of theory) of the target compound.

1. temperatureto cool to RT
2. filtrationfiltered through a little silica gel
3. washThe product was eluted with ethyl acetate
4. customthe solution obtained
5. concentrationwas concentrated under reduced pressure
6. customThe crude product was then purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 1:1)