Lithium Hydroxide → (2-Chlorophenyl) [4-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1H-1,2,3-triazol-1-yl]acetic acid

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Reaction Steps

49 mg (0.09 mmol) of the compound from Example 103 were dissolved in 2 ml of methanol, and 193 μl (0.19 mmol) of a 1 N aqueous lithium hydroxide solution were added. The mixture was stirred at RT for 30 min. The solvent was then removed under reduced pressure, the residue was dissolved in 5 ml of water and the solution was extracted once with 5 ml of ethyl acetate. The organic phase was discarded. The aqueous phase was acidified with 0.2 ml of 1 N hydrochloric acid and extracted twice with in each case 5 ml of ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and concentrated under reduced pressure. This gave 40 mg (83% of theory) of the target compound.

Provenance & Evidence