2-Chlorophenylboronic acid → HCID 69940682, compound

HRID 714733Notes

Reaction equation

HRID 714733 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][N:13]2[C:17](=[O:18])[N:16]([CH2:19][CH:20]([OH:25])[C:21]([F:24])([F:23])[F:22])[C:15]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)=[N:14]2)[CH:3]=1.[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1B(O)O>>[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][N:13]2[C:17](=[O:18])[N:16]([CH2:19][CH:20]([OH:25])[C:21]([F:23])([F:22])[F:24])[C:15]([C:26]3[CH:27]=[CH:28][C:29]([Cl:32])=[CH:30][CH:31]=3)=[N:14]2)[CH:3]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 69939744HCID 69939744, compound

Product 1

HCID 69940682HCID 69940682, compound

Procedure

Analogously to the preparation of Example 122, 265 mg (0.50 mmol) of the compound from Example 104A were reacted with 194 mg (0.74 mmol) of 2-chlorophenylboronic acid. This gave 54 mg (19% of theory) of the target compound of a purity of 98% and 167 mg (49% of theory) of a purity of 83%.

Sources & evidence

ORD record
ord-ad83559188a74de3ab198cfa9ca19b12
Source dataset
uspto-grants-2015_11
Patent number
US09187466B2

Reaction notes

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