HCID 89582530, compound → HCID 89579216, compound

HRID 714771Notes

Reaction equation

HRID 714771 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[N:7][C:6]([C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:10])=[CH:5][CH:4]=1.[H][H]>C(O)C.O.[Pt](=O)=O>[CH3:1][O:2][C:3]1[N:8]=[N:7][C:6]([CH:9]([CH:11]2[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]2)[OH:10])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 89582530HCID 89582530, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 89579216HCID 89579216, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 11139377Platinum dioxide monohydrateCatalystHCID 702EthanolSolvent

Procedure

(6-Methoxypyridazin-3-yl)pyrdin-3-ylmethanone (1.31 g, 6.1 mmol) were dissolved in ethanol (100 ml), platinum(IV) oxide hydrate (80% of Pt, 0.5 g, 2.2 mmol) was added, and the mixture was stirred with supply of hydrogen. Conventional work-up gave 1.26 g (93% yield) of (6-methoxypyridazin-3-yl)piperidin-3-ylmethanol as crude product, which was employed directly in the next step;

Sources & evidence

ORD record
ord-a9e03142f9214e8cb9e99cb4896d3712
Source dataset
uspto-grants-2015_11
Patent number
US09187469B2

Reaction notes

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