Carbamate → HCID 118194968, compound

HRID 714772Notes

Reaction equation

HRID 714772 reaction equation
[CH3:1][C:2]1([C:6]2[CH:7]=[C:8]([NH:18][C:19]([NH2:21])=[O:20])[N:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[N:10]=2)[CH2:5][S:4][CH2:3]1.[C:22](=[O:25])([O-])N.N[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.NC(N)=O>>[CH3:1][C:2]1([C:6]2[CH:7]=[C:8]([NH:18][C:19]([NH:21][C:27]3[CH:32]=[CH:31][C:30]([O:25][C:22]4[CH:8]=[CH:7][CH:6]=[CH:2][CH:1]=4)=[CH:29][CH:28]=3)=[O:20])[N:9]([C:11]3[CH:12]=[CH:13][C:14]([CH3:17])=[CH:15][CH:16]=3)[N:10]=2)[CH2:5][S:4][CH2:3]1

Participants

5

Reactant 4

HCID 276CarbamateHCID 1176UreaHCID 6115AnilineHCID 131734070HCID 131734070, compound

Product 1

HCID 118194968HCID 118194968, compound

Procedure

Preparation of 1-(2-Fluoro-4-phenoxy-phenyl)-3-([5-(3-methyl-thietan-3-yl)-2-p-tolyl-2H-pyrazol-3-yl]-urea (Analog 253). Using Procedure 2, carbamate 29 and aniline 30 are used to synthesize urea Analog 253. LC-MS retention time=3.995 min (M+H=490.4).

Sources & evidence

ORD record
ord-9cebab4ff2814e7f8d82d538dbd35afb
Source dataset
uspto-grants-2015_11
Patent number
US09187470B2

Reaction notes

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