2-(Methylthio)-1H-pyrimidin-4-one → 2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4 (3H)-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(methylsulfanyl)pyrimidin-4(3H)-one (5.2 g) obtained in Step A in diethylene glycol dimethyl ether (50 mL) was added 1-methyl-1H-pyrazol-4-amine (4.1 g), the mixture was stirred overnight at 150° C., and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (5.4 g).

Provenance & Evidence