反应详情

温度

150 °C

To a solution of 2-(methylsulfanyl)pyrimidin-4(3H)-one (5.2 g) obtained in Step A in diethylene glycol dimethyl ether (50 mL) was added 1-methyl-1H-pyrazol-4-amine (4.1 g), the mixture was stirred overnight at 150° C., and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to give the title compound (5.4 g).

1. customthe solvent was evaporated under reduced pressure
2. customThe residue was purified by silica gel column chromatography (ethyl acetate/methanol)