CO2 Methanol MeCN → (3S)-3-isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile

HRID 714790Notes

Reaction equation

HRID 714790 reaction equation
[CH:1]([C:4]1([C:29]#[N:30])[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[CH:18][CH:17]=3)[N:10]=2)[C:5]1=[O:28])([CH3:3])[CH3:2].C(=O)=O.CO.C(#N)C>>[CH:1]([C@:4]1([C:29]#[N:30])[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]3[CH:17]=[CH:18][C:19]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)=[CH:20][CH:21]=3)[N:10]=2)[C:5]1=[O:28])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 86678958CO2 Methanol MeCNHCID 1178403133-Isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile

Product 1

HCID 117840810(3S)-3-isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrileYield 10.6%

Procedure

3-Isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile (85 mg) obtained in Example 5 was resolved by SFC (column: CHIRALCEL OJH, 20 mmID×250 mmL, manufactured by Daicel Chemical Industries, mobile phase: carbon dioxide/methanol/acetonitrile 660/170/170), and the compound having a longer retention time was recrystallized (hexane/ethyl acetate) to give the title compound (9 mg).

Workup

  1. customwas recrystallized (hexane/ethyl acetate)

Sources & evidence

ORD record
ord-e3be759de0d54d90a73b5d115a84d069
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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