CO2 Methanol MeCN → (3S)-3-isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	CO2 Methanol MeCN	HCID 86678958	—
Reactant	3-Isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile	HCID 117840313	—
Product	(3S)-3-isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile	HCID 117840810	10.6%

Reaction Steps

3-Isopropyl-1-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)-2-oxopyrrolidine-3-carbonitrile (85 mg) obtained in Example 5 was resolved by SFC (column: CHIRALCEL OJH, 20 mmID×250 mmL, manufactured by Daicel Chemical Industries, mobile phase: carbon dioxide/methanol/acetonitrile 660/170/170), and the compound having a longer retention time was recrystallized (hexane/ethyl acetate) to give the title compound (9 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09187453B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-e3be759de0d54d90a73b5d115a84d069
Source note	uspto-grants-2015_11