反应详情

1-(2-Chloropyrimidin-4-yl)-3-ethyl-2-oxopyrrolidine-3-carbonitrile (7.8 g) obtained in Step A of Example 2 was resolved by HPLC (column: CHIRALPAK IC, 50 mmID×500 mmL, manufactured by Daicel Chemical Industries, mobile phase: hexane/2-propanol=200/800) to give the title compound (3.5 g) having a shorter retention time.