Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714791Generated: October 30, 2026

1-(2-Chloro-4-pyrimidinyl)-3-ethyl-2-oxo-3-pyrrolidinecarbonitrile → (3R)-1-(2-chloropyrimidin-4-yl)-3-ethyl-2-oxopyrrolidine-3-carbonitrile

https://huagongshe.com/reaction/714791

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chloro-4-pyrimidinyl)-3-ethyl-2-oxo-3-pyrrolidinecarbonitrileHCID 117840738—
SolventIsopropanol hexaneHCID 21585144—
Product(3R)-1-(2-chloropyrimidin-4-yl)-3-ethyl-2-oxopyrrolidine-3-carbonitrileHCID 11784066544.9%

Reaction Steps

1-(2-Chloropyrimidin-4-yl)-3-ethyl-2-oxopyrrolidine-3-carbonitrile (7.8 g) obtained in Step A of Example 2 was resolved by HPLC (column: CHIRALPAK IC, 50 mmID×500 mmL, manufactured by Daicel Chemical Industries, mobile phase: hexane/2-propanol=200/800) to give the title compound (3.5 g) having a shorter retention time.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187453B2
Source datasetuspto-grants-2015_11
ORD IDord-72ccd12b064f4b13a3935b20b9e2415b
Source noteuspto-grants-2015_11