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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714793Generated: October 30, 2026

1-(2-Chloropyrimidin-4-yl)-3-isopropyl-2-oxopyrrolidine-3-carbonitrile → (3S)-1-(2-chloropyrimidin-4-yl)-3-isopropyl-2-oxopyrrolidine-3-carbonitrile

https://huagongshe.com/reaction/714793

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Chloropyrimidin-4-yl)-3-isopropyl-2-oxopyrrolidine-3-carbonitrileHCID 117840501—
SolventIsopropanol hexaneHCID 21585144—
Product(3S)-1-(2-chloropyrimidin-4-yl)-3-isopropyl-2-oxopyrrolidine-3-carbonitrileHCID 11784006848.9%

Reaction Steps

1-(2-Chloropyrimidin-4-yl)-3-isopropyl-2-oxopyrrolidine-3-carbonitrile (14.1 g) obtained in Step C of Example 5 was resolved by HPLC (column: CHIRALPAK IC, 50 mmID×500 mmL, manufactured by Daicel Chemical Industries, mobile phase: hexane/2-propanol=200/800) to give the title compound (6.9 g) having a shorter retention time.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187453B2
Source datasetuspto-grants-2015_11
ORD IDord-0401a8fe856e4dbd8a7c08ea8c460193
Source noteuspto-grants-2015_11