HCID 117840516, compound → 2-(4-amino-1H-pyrazol-1-yl)-2-methylpropanamide

HRID 714826Notes

Reaction equation

HRID 714826 reaction equation
[CH3:1][C:2]([N:7]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[N:8]1)([CH3:6])[C:3]([NH2:5])=[O:4]>C(O)C.[C].[Pd]>[NH2:12][C:10]1[CH:9]=[N:8][N:7]([C:2]([CH3:6])([CH3:1])[C:3]([NH2:5])=[O:4])[CH:11]=1

Participants

4

Reactant 1

HCID 117840516HCID 117840516, compound

Product 1

HCID 896508202-(4-amino-1H-pyrazol-1-yl)-2-methylpropanamideYield 89.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of 2-methyl-2-(4-nitro-1H-pyrazol-1-yl)propanamide (1.0 g) obtained in Step B of Example 109 in ethanol (50 mL) was added 10% palladium-carbon (100 mg), and the mixture was stirred at room temperature for 5 hr under hydrogen atmosphere (at normal pressure). The palladium carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was recrystallized (ethyl acetate/hexane) to give the title compound (760 mg).

Workup

  1. customThe palladium carbon was removed by filtration through Celite
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was recrystallized (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-16e4a92c91d942f997b86e179975b878
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

Loading…