反应详情

To a solution of 2-methyl-2-(4-nitro-1H-pyrazol-1-yl)propanamide (1.0 g) obtained in Step B of Example 109 in ethanol (50 mL) was added 10% palladium-carbon (100 mg), and the mixture was stirred at room temperature for 5 hr under hydrogen atmosphere (at normal pressure). The palladium carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was recrystallized (ethyl acetate/hexane) to give the title compound (760 mg).

1. customThe palladium carbon was removed by filtration through Celite
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was recrystallized (ethyl acetate/hexane)