HCID 117840516, compound → 2-(4-amino-1H-pyrazol-1-yl)-2-methylpropanamide

Participants

Reaction Steps

To a solution of 2-methyl-2-(4-nitro-1H-pyrazol-1-yl)propanamide (1.0 g) obtained in Step B of Example 109 in ethanol (50 mL) was added 10% palladium-carbon (100 mg), and the mixture was stirred at room temperature for 5 hr under hydrogen atmosphere (at normal pressure). The palladium carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was recrystallized (ethyl acetate/hexane) to give the title compound (760 mg).

Provenance & Evidence