Triethylamine → HCID 117840596, compound

HRID 714828Notes

Reaction equation

HRID 714828 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:9]=[N:10][N:11]([C:13]([CH3:17])([CH3:16])[CH2:14][OH:15])[CH:12]=1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>O>[CH3:26][S:27]([O:15][CH2:14][C:13]([N:11]1[CH:12]=[C:8]([NH:7][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:18])[CH:9]=[N:10]1)([CH3:17])[CH3:16])(=[O:29])=[O:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 131734074HCID 131734074, compound

Product 1

HCID 117840596HCID 117840596, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To tert-butyl(1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl)carbamate (3.4 g) obtained in Step A of Example 114 were added successively triethylamine (2.4 mL) and methanesulfonyl chloride (1.2 mL) in an ice bath, and the mixture was stirred at room temperature for 2 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the crude title compound (2.2 g).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe obtained organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-fb33bdec3cd043ec8ec4984cfeefabf3
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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