1-(4-Nitro-1H-pyrazol-1-yl)cyclobutanemethanol → 1-(4-Amino-1h-pyrazol-1-yl)cyclobutanemethanol

HRID 714838Notes

Reaction equation

HRID 714838 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]2([CH2:13][OH:14])[CH2:12][CH2:11][CH2:10]2)[CH:8]=1)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([C:9]2([CH2:13][OH:14])[CH2:12][CH2:11][CH2:10]2)[CH:8]=1

Participants

4

Reactant 1

HCID 1178406451-(4-Nitro-1H-pyrazol-1-yl)cyclobutanemethanol

Product 1

HCID 916187111-(4-Amino-1h-pyrazol-1-yl)cyclobutanemethanolYield 98.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of (1-(4-nitro-1H-pyrazol-1-yl)cyclobutyl)methanol (480 mg) obtained in Step B of Example 127 in ethanol (30 mL) was added 10% palladium-carbon (100 mg), and the mixture was stirred at room temperature for 10 hr under hydrogen atmosphere (at normal pressures). The palladium-carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure to give the title compound (400 mg).

Workup

  1. customThe palladium-carbon was removed by filtration through Celite
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-047b0ba202a240b28179a5b002e23c27
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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