1-(4-Nitro-1H-pyrazol-1-yl)cyclobutanemethanol → 1-(4-Amino-1h-pyrazol-1-yl)cyclobutanemethanol

Participants

Reaction Steps

To a solution of (1-(4-nitro-1H-pyrazol-1-yl)cyclobutyl)methanol (480 mg) obtained in Step B of Example 127 in ethanol (30 mL) was added 10% palladium-carbon (100 mg), and the mixture was stirred at room temperature for 10 hr under hydrogen atmosphere (at normal pressures). The palladium-carbon was removed by filtration through Celite, and the solvent was evaporated under reduced pressure to give the title compound (400 mg).

Provenance & Evidence