Ammonia → 1-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxamide

HRID 714844Notes

Reaction equation

HRID 714844 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]2([C:13]([O:15]CC)=O)[CH2:12][CH2:11][CH2:10]2)[CH:8]=1)([O-:3])=[O:2].[NH3:18]>CO>[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]2([C:13]([NH2:18])=[O:15])[CH2:10][CH2:11][CH2:12]2)[CH:8]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 117840093ethyl 1-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxylate

Product 1

HCID 1178404001-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of ethyl 1-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxylate (300 mg) obtained in Step A of Example 127 and 8 M ammonia in methanol (15 mL) was stirred at room temperature for 10 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (260 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1c8aff741ad14d9a8e2fc32e609c97b4
Source dataset
uspto-grants-2015_11
Patent number
US09187453B2

Reaction notes

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