HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | ethyl 1-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxylate | HCID 117840093 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxamide | HCID 117840400 | — |
Reaction Steps
A mixture of ethyl 1-(4-nitro-1H-pyrazol-1-yl)cyclobutanecarboxylate (300 mg) obtained in Step A of Example 127 and 8 M ammonia in methanol (15 mL) was stirred at room temperature for 10 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (260 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187453B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-1c8aff741ad14d9a8e2fc32e609c97b4 |
| Source note | uspto-grants-2015_11 |