反应详情

温度

90 °C

To a solution of (3S)-1-(2-chloropyrimidin-4-yl)-3-cyclopropyl-2-oxopyrrolidine-3-carbonitrile (100 mg) obtained in Step E of Example 103, tert-butyl 4-amino-2-ethoxybenzoate (110 mg) obtained in Step C of Example 139, cesium carbonate (250 mg) and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (35 mg) in tetrahydrofuran (3.0 mL) was added tris(dibenzylideneacetone)dipalladium(0) (34 mg) under argon atmosphere, and the mixture was stirred overnight at 90° C. The insoluble substance was removed by filtration through Celite, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (41 mg).

1. customThe insoluble substance was removed by filtration through Celite
2. customthe solvent was evaporated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)