Hydrochloric Acid → HCID 117840198, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of tert-butyl 4-(4-((4-((3S)-3-cyano-3-isopropyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)phenyl)tetrahydro-2H-pyran-4-carboxylate (30 mg) obtained in Example 299 in water (5.0 mL) was added 2 M hydrochloric acid (3.0 mL), and the mixture was stirred at 100° C. for 1 hr. The solvent was evaporated under reduced pressure, and the residue was crystallized (diisopropyl ether/ethyl acetate) to give the title compound (7.5 mg).

Provenance & Evidence