Hydrochloric Acid → HCID 117840198, compound

HRID 714883Notes

Reaction equation

[C:1]([C@@:3]1([CH:35]([CH3:37])[CH3:36])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4([C:27]([O:29]C(C)(C)C)=[O:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[CH:17][CH:16]=3)[N:9]=2)[C:4]1=[O:34])#[N:2].[ClH:38]>O>[ClH:38].[C:1]([C@@:3]1([CH:35]([CH3:37])[CH3:36])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[CH:17][C:18]([C:21]4([C:27]([OH:29])=[O:28])[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)=[CH:19][CH:20]=3)[N:9]=2)[C:4]1=[O:34])#[N:2]

Participants

Conditions

Temperature: 100 °C

Procedure

To a suspension of tert-butyl 4-(4-((4-((3S)-3-cyano-3-isopropyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)phenyl)tetrahydro-2H-pyran-4-carboxylate (30 mg) obtained in Example 299 in water (5.0 mL) was added 2 M hydrochloric acid (3.0 mL), and the mixture was stirred at 100° C. for 1 hr. The solvent was evaporated under reduced pressure, and the residue was crystallized (diisopropyl ether/ethyl acetate) to give the title compound (7.5 mg).

Workup

customThe solvent was evaporated under reduced pressure
customthe residue was crystallized (diisopropyl ether/ethyl acetate)

Sources & evidence

ORD record: ord-474fb75329634a429a178edf8111897f
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09187453B2

Reaction notes

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