反应详情

(4-Chloro-3-fluoro-phenyl)-(1-methyl-1H-pyrazol-3-yl)-methylamine (32a) was prepared analogously except oxazole-5-carbaldehyde was replaced with 1-methyl-1H-pyrazole-3-carbaldehyde (CASRN 27258-32-8) and (4-chloro-3-fluorophenyl)magnesium bromide was used in place of (3,4-dichlorophenyl)magnesium bromide in step 2. (4-Chloro-3-fluoro-phenyl)-(1-ethyl-1H-pyrazol-3-yl)-methylamine (32b) was prepared analogously except oxazole-5-carbaldehyde was replaced with 1-ethyl-1H-pyrazole-3-carbaldehyde (CASRN 942319-16-6).