HCID 118363874, compound → HCID 71248026, compound

HRID 715062Notes

Reaction equation

HRID 715062 reaction equation
C(OC([NH:11][C@@H:12]([C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[C:27]([F:35])[CH:26]=1)[C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=O)C1C=CC=CC=1>[Pd].CCO>[NH2:11][C@@H:12]([C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:33])([F:32])[F:34])=[C:27]([F:35])[CH:26]=1)[C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]

Participants

4

Reactant 1

HCID 118363874HCID 118363874, compound

Product 1

HCID 71248026HCID 71248026, compoundYield 68.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 61 (1.04 g, 2.09 mmol) and EtOH (25 mL), was added Pd/C (10% Degussa wet, 0.5 g). The mixture was hydrogenated overnight under balloon pressure. The mixture was then filtered and evaporated to afford 0.52 g (68.5%) of 63 as thick oil.

Workup

  1. filtrationThe mixture was then filtered
  2. customevaporated

Sources & evidence

ORD record
ord-ad0b07b062744187820822a95aa32aab
Source dataset
uspto-grants-2015_11
Patent number
US09187462B2

Reaction notes

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