HRID715078

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID71246992

未命名化合物

HCID71247008

未命名化合物

HCID71247330

未命名化合物

PRODUCTS

生成物

结构：COc1ccc([C@H](NC(=O)c2cc(F)c3cnc(NCC4COC4)nc3c2)c2cnn(C)c2)cc1F

HCID71247692

未命名化合物

PROCEDURE

实验过程

5-Fluoro-2-[(oxetan-3-ylmethyl)-amino]-quinazoline-7-carboxylic acid [(S)-(3-fluoro-4-methoxy-phenyl)-(1-methyl-1H-pyrazol-4-yl)-methyl]-amide (I-63) was prepared analogously except 32b was replaced with 40f and 84b was replaced with 87f.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-186797bf347544d2aab701e74eea513e
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09187462B2
来源说明: uspto-grants-2015_11

反应 SMILES

ClC1C=CC([C@@H](C2C=CN(C)N=2)N)=CC=1F.[F:17][C:18]1[CH:19]=[C:20]([C@@H:26]([C:28]2[CH:29]=[N:30][N:31]([CH3:33])[CH:32]=2)[NH2:27])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25].[F:34][C:35]1[CH:44]=[C:43]([C:45](O)=[O:46])[CH:42]=[C:41]2[C:36]=1[CH:37]=[N:38][C:39]([NH:48][CH2:49][CH:50]1[CH2:53][O:52][CH2:51]1)=[N:40]2>>[F:17][C:18]1[CH:19]=[C:20]([C@H:26]([NH:27][C:45]([C:43]2[CH:42]=[C:41]3[C:36]([CH:37]=[N:38][C:39]([NH:48][CH2:49][CH:50]4[CH2:51][O:52][CH2:53]4)=[N:40]3)=[C:35]([F:34])[CH:44]=2)=[O:46])[C:28]2[CH:29]=[N:30][N:31]([CH3:33])[CH:32]=2)[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]