HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-[(oxetan-3-ylmethyl)-amino]-quinazoline-7-carboxylic acid → 5-Fluoro-2-[(oxetan-3-ylmethyl)-amino]-quinazoline-7-carboxylic acid [(S)-(3-fluoro-4-methoxy-phenyl)-(1-methyl-1H-pyrazol-4-yl)-methyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-[(oxetan-3-ylmethyl)-amino]-quinazoline-7-carboxylic acid | HCID 71246992 | — |
| Reactant | (5)-(3-Fluoro-4-methoxyphenyl)(1-methyl-1H-pyrazol-4-yl)methanamine | HCID 71247008 | — |
| Reactant | (S)-(4-chloro-3-fluorophenyl)(1-methyl-1H-pyrazol-3-yl)methanamine | HCID 71247330 | — |
| Product | 5-Fluoro-2-[(oxetan-3-ylmethyl)-amino]-quinazoline-7-carboxylic acid [(S)-(3-fluoro-4-methoxy-phenyl)-(1-methyl-1H-pyrazol-4-yl)-methyl]-amide | HCID 71247692 | — |
Reaction Steps
5-Fluoro-2-[(oxetan-3-ylmethyl)-amino]-quinazoline-7-carboxylic acid [(S)-(3-fluoro-4-methoxy-phenyl)-(1-methyl-1H-pyrazol-4-yl)-methyl]-amide (I-63) was prepared analogously except 32b was replaced with 40f and 84b was replaced with 87f.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187462B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-186797bf347544d2aab701e74eea513e |
| Source note | uspto-grants-2015_11 |