Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylate → HCID 89875005, compound

HRID 715227Notes

Reaction equation

HRID 715227 reaction equation
Br[CH2:2][C:3]1[C:12]([Cl:13])=[N:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=O.Cl.[F:15][C:16]([F:28])([F:27])[CH2:17][O:18][C:19]1[N:24]=[C:23]([CH2:25][NH2:26])[CH:22]=[CH:21][CH:20]=1>>[Cl:13][C:12]1[C:3]2[CH2:2][N:26]([CH2:25][C:23]3[CH:22]=[CH:21][CH:20]=[C:19]([O:18][CH2:17][C:16]([F:28])([F:15])[F:27])[N:24]=3)[C:5](=[O:7])[C:4]=2[CH:9]=[CH:10][N:11]=1

Participants

3

Reactant 2

HCID 72213786Methyl 3-(bromomethyl)-2-chloropyridine-4-carboxylateHCID 89874548HCID 89874548, compound

Product 1

HCID 89875005HCID 89875005, compoundYield 60%

Procedure

The title compound is prepared in 60% yield (31 mg, white solid) from methyl 3-(bromomethyl)-2-chloroisonicotinate (38 mg, 0.14 mmol) and (6-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanamine hydrochloride (35 mg, 0.14 mmol, Amine-19) in a similar manner to Intermediate-2.

Sources & evidence

ORD record
ord-b6a14bb7ce3342d6b4cbf197ebfd3e1b
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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