HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(bromomethyl)-2-chloroisonicotinate → 4-chloro-2-(3-methyl-4-(2,2,2-trifluoroethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(bromomethyl)-2-chloroisonicotinate | HCID 89874240 | — |
| Reactant | 3-Methyl-4-(2,2,2-trifluoro-ethoxy)-benzylamine; hydrochloride | HCID 89875075 | — |
| Product | 4-chloro-2-(3-methyl-4-(2,2,2-trifluoroethoxy)benzyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one | HCID 89875188 | 99% |
Reaction Steps
The title compound is prepared in 99% yield (460 mg, white solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (350 mg, 1.26 mmol) and (3-methyl-4-(2,2,2-trifluoroethoxy)phenyl)methanamine hydrochloride (353 mg, 1.38 mmol, Amine-34) in a similar manner to Intermediate-2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-c1e240c581cf4e91add08270113aa788 |
| Source note | uspto-grants-2015_11 |