620608-63-1 → HCID 89874423, compound

HRID 715256Notes

Reaction equation

HRID 715256 reaction equation
Br[CH2:2][C:3]1[C:13]([Cl:14])=[N:12][CH:11]=[CH:10][C:4]=1[C:5]([O:7]CC)=O.[F:15][C:16]1[CH:30]=[CH:29][C:19]([O:20][C:21]2[N:26]=[CH:25][C:24]([CH2:27][NH2:28])=[CH:23][CH:22]=2)=[CH:18][CH:17]=1>>[Cl:14][C:13]1[C:3]2[CH2:2][N:28]([CH2:27][C:24]3[CH:25]=[N:26][C:21]([O:20][C:19]4[CH:29]=[CH:30][C:16]([F:15])=[CH:17][CH:18]=4)=[CH:22][CH:23]=3)[C:5](=[O:7])[C:4]=2[CH:10]=[CH:11][N:12]=1

Participants

3

Reactant 2

HCID 16786006620608-63-1HCID 89874240Ethyl 3-(bromomethyl)-2-chloroisonicotinate

Product 1

HCID 89874423HCID 89874423, compoundYield 54%

Procedure

The title compound is prepared in 54% yield (130 mg, white solid) from ethyl 3-(bromomethyl)-2-chloroisonicotinate (180 mg, 0.64 mmol, Step-1 of Intermediate-1) and (6-(4-fluorophenoxy)pyridin-3-yl)methanamine (140 mg, 0.64 mmol, Amine-18) in a similar manner to Intermediate-2.

Sources & evidence

ORD record
ord-1e29dc74909747b8ac68d225cef88c63
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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