Phenyl formate → HCID 89875126, compound

HRID 715297Notes

Reaction equation

Cl[C:2]1[C:7]2[CH2:8][N:9]([CH2:12][C:13]3[N:14]=[N:15][C:16]([O:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[C:17]([CH3:19])[CH:18]=3)[C:10](=[O:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH:26]([O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:27]>>[CH3:19][C:17]1[CH:18]=[C:13]([CH2:12][N:9]2[C:10](=[O:11])[C:6]3[CH:5]=[CH:4][N:3]=[C:2]([C:26]([O:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[O:27])[C:7]=3[CH2:8]2)[N:14]=[N:15][C:16]=1[O:20][CH2:21][C:22]([F:25])([F:24])[F:23]

Participants

Reactant 2

HCID 74626Phenyl formate

HCID 89874983HCID 89874983, compound

Product 1

HCID 89875126HCID 89875126, compoundYield 64%

Procedure

The title compound is prepared in 64% yield (130 mg, colorless solid) from 4-chloro-2-((5-methyl-6-(2,2,2-trifluoroethoxy)pyridazin-3-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one (170 mg, 0.46 mmol, Intermediate-67) and phenyl formate (110 mg, 0.91 mmol) in a similar manner to Intermediate-91.

Sources & evidence

ORD record: ord-8d44fcd652274981b9b87ae4d8f55509
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09187475B2

Reaction notes

Loading…