Phenyl formate → HCID 89874980, compound

HRID 715305Notes

Reaction equation

Cl[C:2]1[C:7]2[CH2:8][N:9]([CH2:12][C:13]3[CH:18]=[C:17]([CH3:19])[C:16]([O:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[CH:15][N:14]=3)[C:10](=[O:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[CH:26]([O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:27]>>[CH3:19][C:17]1[C:16]([O:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[CH:15][N:14]=[C:13]([CH2:12][N:9]2[C:10](=[O:11])[C:6]3[CH:5]=[CH:4][N:3]=[C:2]([C:26]([O:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[O:27])[C:7]=3[CH2:8]2)[CH:18]=1

Participants

Reactant 2

HCID 74626Phenyl formate

HCID 89874588HCID 89874588, compound

Product 1

HCID 89874980HCID 89874980, compoundYield 71%

Procedure

The title compound is prepared in 71% yield (130 mg, brown solid) from 4-chloro-2-((4-methyl-5-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one (150 mg, 0.40 mmol, Intermediate-74) and phenyl formate (99 mg, 0.81 mmol) in a similar manner to Intermediate-91.

Sources & evidence

ORD record: ord-297dbc44949040cbb730e389d25b84e1
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09187475B2

Reaction notes

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