Ethylamine → HCID 89874442, compound

HRID 715318Notes

Reaction equation

HRID 715318 reaction equation
[C:1]([O:5][C:6]([C:8]1[CH:33]=[CH:32][C:11]([CH2:12][N:13]2[C:21](=[O:22])[C:20]3[CH:19]=[CH:18][N:17]=[C:16]([C:23]([O:25]C4C=CC=CC=4)=O)[C:15]=3[CH2:14]2)=[CH:10][C:9]=1[CH3:34])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:35]([NH2:37])[CH3:36]>>[CH2:35]([NH:37][C:23]([C:16]1[C:15]2[CH2:14][N:13]([CH2:12][C:11]3[CH:32]=[CH:33][C:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[C:9]([CH3:34])[CH:10]=3)[C:21](=[O:22])[C:20]=2[CH:19]=[CH:18][N:17]=1)=[O:25])[CH3:36]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 89874038HCID 89874038, compound

Product 1

HCID 89874442HCID 89874442, compoundYield 99%

Procedure

The title compound is prepared in >99% yield (260 mg, pale brown solid) from phenyl 2-(4-(tert-butoxycarbonyl)-3-methylbenzyl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate (270 mg, 0.59 mmol, Step-2) and ethylamine (0.14 mL, 1.8 mmol, 70% aqueous solution) in a similar manner to Example-435 (Method-G).

Sources & evidence

ORD record
ord-975f5a87d1294a9f96687350986dba9d
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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