HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoroethan-1-ol → 6-(2,2-Difluoroethoxy)-5-methylnicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoroethan-1-ol | HCID 136187 | — |
| Reactant | 6-Fluoro-5-methylpyridine-3-carboxylic acid | HCID 16414223 | — |
| Product | 6-(2,2-Difluoroethoxy)-5-methylnicotinic acid | HCID 87426413 | 73% |
Reaction Steps
The title compound is prepared in 73% yield (1.02 g, an off-white solid) from 6-fluoro-5-methylnicotinic acid (1.00 g, 6.45 mmol) and 2,2-difluoroethanol instead of 2,2,2-trifluoroethanol (1.06 g, 12.9 mmol) in a similar manner to Step-1 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-c05be71dd77f4ccbba7deffa7d4766fe |
| Source note | uspto-grants-2015_11 |