3,3,3-Trifluoro-1-propanol → HCID 66802967, compound

HRID 715368Notes

Reaction equation

HRID 715368 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[F:12][C:13]([F:18])([F:17])[CH2:14][CH2:15][OH:16]>>[F:12][C:13]([F:18])([F:17])[CH2:14][CH2:15][O:16][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 1375123,3,3-Trifluoro-1-propanolHCID 254249Methyl 6-chloropyridine-3-carboxylate

Product 1

HCID 66802967HCID 66802967, compoundYield 47%

Procedure

The title compound is prepared in 47% yield (1.37 g, colorless oil) from methyl 6-chloronicotinate (2.0 g, 11.7 mmol) and 3,3,3-trifluoropropan-1-ol instead of 2,2,2-trifluoroethanol in a similar manner to Step-3 of Amine-9.

Sources & evidence

ORD record
ord-fb0fa8773f5f453aa71fe1c8b7e0d2c7
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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