Dodecylamine → HCID 67508769, compound

HRID 715385Notes

Reaction equation

[F:1][C:2]1[C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:17]CCCCCCCCCCCN>>[F:1][C:2]1[C:3]([O:11][CH2:12][C:13]([F:15])([F:16])[F:14])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([O:9][CH3:17])=[O:8]

Participants

Reactant 2

HCID 13583Dodecylamine

HCID 67510084HCID 67510084, compound

Product 1

HCID 67508769HCID 67508769, compoundYield 55%

Procedure

The title compound is prepared in 55% yield (1.74 g, white solid) from 5-fluoro-6-(2,2,2-trifluoroethoxy)nicotinic acid (3.0 g, 12.6 mmol, Step-1) in a similar manner to Step-2 of Amine-12.

Sources & evidence

ORD record: ord-1ce90866be024d8c8cdf6b26fffb3ca8
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09187475B2

Reaction notes

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