tert-Butylsulfinamide, (R)-(+)- → HCID 89874378, compound

HRID 715401Notes

Reaction equation

HRID 715401 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:15](=O)[CH3:16])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12].[CH3:18][C:19]([S@:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>>[CH3:18][C:19]([S@:22]([NH:24][CH:15]([C:4]1[CH:5]=[N:6][C:7]([O:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])=[C:2]([CH3:1])[CH:3]=1)[CH3:16])=[O:23])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874740HCID 89874740, compound

Product 1

HCID 89874378HCID 89874378, compoundYield 65%

Procedure

The title compound is prepared in 65% yield (1.50 g, colorless oil) from 1-(5-methyl-6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethanone (1.63 g, 6.59 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-408cca84cd4c477a9cfdd1cacb9468ac
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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