tert-Butylsulfinamide, (S)-(-)- → HCID 89875522, compound

HRID 715402Notes

Reaction equation

HRID 715402 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:14](=O)[CH3:15])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[CH3:17][C:18]([S@@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@@:21]([NH:23][CH:14]([C:4]1[CH:5]=[N:6][C:7]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[C:2]([CH3:1])[CH:3]=1)[CH3:15])=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 11355477tert-Butylsulfinamide, (S)-(-)-HCID 67510144HCID 67510144, compound

Product 1

HCID 89875522HCID 89875522, compoundYield 83%

Procedure

The title compound is prepared in 83% yield (0.79 g, colorless oil) from 1-(5-methyl-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanone (0.66 g, 2.81 mmol, Step-3 of Amine-2) and (S)-2-methylpropane-2-sulfinamide in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-b5736fc77c24489b9343e602f86250f1
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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